This event will bring together leading clinicians, scientists as well as early age onset (EAO) colorectal cancer (CRC) survivors and Caregivers from across the country and internationally . The program will provide extensive opportunities for participants to advance their understanding of the rapidly increasing incidence of rectal and colon cancer among young adults under 50 years of age in the U.S. and abroad.

This groundbreaking program will, for a fifth consecutive year, provide all participants the opportunity to hear and question leading clinicians and researchers on the life saving potential of timely clinical risk assessment / family cancer health history; earliest possible stage, optimal, fertility preserving clinical care, as well as the latest information regarding national and international EAO CRC incidence trends, pathogenesis, and genetics. In addition, this year’s program will present a “Research in Progress” segment featuring currently NCI funded and planned EAO CRC research  projects from across America and Europe. Again this year, important Break-Out Sessions based on needs-assessments from our survivor community will address challenging issues surrounding Palliative Care, support networks for “Caregivers” and a “Primer” on the “Epigenetics” of EAO CRC specifically requested by our Young Adult CRC Survivor Program Advisory Group.

The course will include lectures, workshops and panel discussions designed to advance the “state-of-the-science” addressing EAO-CRC. Our faculty will once again be world class speakers representing leading academic medical centers with major additional inspiring programmatic contributions from the Early Age Onset Colorectal Cancer Survivor Community of the United States and beyond.

• Provide an expert review of the latest published information on the increasing incidence and mortality associated with Early Age Onset Colorectal Cancer in the United States and globally.
• Review the State-of-the-Science regarding the known and possible causes of the increasing incidence of EAO-CRC including alterations in our food and water supply, the contribution of novel germline genetic factors and etiologic clues based on the molecular biology of EAO-CRC cancers.
• Provide an evidence-based framework for reducing risk, increasing early stage diagnosis and improving treatment and outcomes for young adult colorectal cancer patients.
• Define the “Gaps” in our current understanding of Early Age Onset Colorectal Cancer in order to set our clinical and research priorities and develop a strategic plan to reduce EAO-CRC incidence and mortality.

THURSDAY, MAY 2, 2019

7:00 AM – 8:00 AM REGISTRATION AND BREAKFAST

8:00 AM – 8:30 AM FRAMING THE CONVERSATION: STRATEGIC CHALLENGES IN CURRENT MEDICAL CARE THAT CONTRIBUTE TO YOUNG ADULT COLORECTAL CANCER (CRC) INCIDENCE AND MORTALITY. SURVIVOR TESTIMONIALS UNDERSCORE OPPORTUNITIES FOR IMPROVEMENT IN THE PREVENTION AND CARE OF YOUNG ADULT COLORECTAL CANCER.

• Chelsea Boet,Sarah Debord, Kevin Hays, Kim Newcomer, Susan Pfau, Eric Reddy, Valarie Schlosser, Diana Sloan, Denelle Suranski, Tabitha Trent, Wes Hensel
• Opening Remarks: Richard R. Barakat, MD, Physician-in-Chief and Director, Northwell Health Cancer Institute
• How the Survivor Testimonials Framed Today’s Program: Thomas K. Weber, MD, FACS, Northwell Health, Colon Cancer Foundation
• Housekeeping: Cindy R. Borassi, Colon Cancer Foundation  

8:30 AM – 9:35 AM SESSION I: THE DIMENSIONS OF THE EAO-CRC PROBLEM: TARGET ITEM: ACCURATE, REGULAR, UP TO DATE MEASUREMENT OF KEY METRICS DESCRIBING THE EARLY AGE ONSET COLORECTAL CANCER PUBLIC HEALTH CRISIS.

8:30 AM – 8:40 AM

• Overview of Global EAO-CRC Incidence Patterns and Trends
  • Thomas K. Weber, MD, FACS, Northwell Health, Colon Cancer Foundation

8:40 AM – 8:50 AM

• Overview of United States EAO-CRC Incidence Patterns and  Trends
  • Rebecca L. Siegel, MPH, American Cancer Society

8:50 AM – 9:00 AM

• Utilization of Detailed Centers  for Disease Control (CDC) Cancer Registry Data in the Age of Genomic Medicine
  • Jordan Karlitz, MD, FACG Tulane University School of Medicine  (VIA VIDEO CONFERENCING)

9:00 AM – 9:10 AM

• Overview of European Cancer Registries Data Resources on EAO-CRC
  • Irit Ben-Aharon, MD, PhD, Rambam Health Care Campus, Haifa, Israel, European Organisation for Research and Treatment of Cancer (EORTC)

9:10 AM – 9:20 AM

• Survey of Young Onset Patients, Survivors, and Caregivers: Self-Reported Clinical, Psychosocial, Financial and Quality of Life Experiences.
  • Ronit Yarden, Ph.D. MHSA, Colorectal Cancer Alliance

9:20 AM – 9:35 AM

• Q&A Panel Discussion – Strategic Plan Development

9:35 AM – 9:50 AM

• Networking, Coffee, Poster Viewing Break

9:50 AM – 11:35 AM  SESSION II: FAMILY HISTORY ASCERTAINMENT IN THE U.S. (ADDRESSING  GAP 1) WHAT STEPS ARE NEEDED TO IMPROVE THE WELL DOCUMENTED LESS THAN OPTIMAL STATUS OF THIS SITUATION? WHAT IS OUR BEST INFORMATION ON THE DOCUMENTATION OF CANCER FAMILY HISTORY IN PRIMARY CARE?  WHAT ARE THE KEY ELEMENTS REQUIRED FOR SUCCESS.

Moderator:  Gregory Feero, MD, PhD, Maine Dartmouth Family Medicine Residency, Augusta, ME; Geisel School of Medicine at Dartmouth, Hanover, NH

9:50 AM – 10:10 AM

• Electronic Health Records (EHR) and family cancer history ascertainment. The path forward?   
  • Gregory Feero, MD, PhD, Maine Dartmouth Family Medicine Residency, Augusta, ME; Geisel School of Medicine at Dartmouth, Hanover, NH

10:10 AM – 10:25 AM

• Review of National Colorectal Cancer Roundtable (NCCRT) Family Health History Early Age Onset Colorectal Cancer (EAO-CRC) Task Group Progress  and Overview of the NCCRT Risk Assessment and Screening Toolkit to Detect Familial, Hereditary and Early Onset Colorectal Cancer and next steps for dissemination and implementation
  • Dennis Ahnen, MD, AGAF, FACG, University of Colorado School of Medicine, Gastroenterology of the Rockies

10:25 AM – 10:40 AM

• Implementation plan for 2018 American Cancer Society recommendations (and rationale) for screening for the early detection of colorectal cancer.
  • Robert A. Smith, PhD, American Cancer Society

10:40 AM – 10:50 AM

• Strategies for Addressing Early Onset CRC: An NCCRT Report
  • Jan Lowery, Colorado Center for Personalized Medicine

10:50 AM – 11:00 AM

• Detecting Unaffected Individuals with Lynch Syndrome (DUAL).  
  • Sayoni Lahiri, MS, CGC, UT Southwestern Medical Center

11:00 AM – 11:10 AM

• Prevalence of Advanced Colorectal Polyps Among First Degree Relatives of EOCRC patients
  • Christine L. Sardo Molmenti, PhD, MPH Feinstein Institute for Medical Research, Northwell Health, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell

11:10 AM – 11:15 AM  

• Integrating education on the importance of family health history ascertainment and earliest possible diagnosis into the entire continuum of medical and specialty education from medical school through Board Certification, CME and Recertification.
  • Thomas K. Weber, MD, FACS, Northwell Health, Colon Cancer Foundation

11:15 AM – 11:30 AM

• Q&A Panel Discussion – Strategic Plan Development

11:30 AM – 12:15 PM

LUNCH

12:15 PM – 1:20 PM SESSION III: EARLIEST POSSIBLE DIAGNOSIS AND TREATMENT THROUGH TIMELY RECOGNITION OF THE SYMPTOMS AND SIGNS OF YOUNG ADULT CRC (ADDRESSING GAP 2)

Moderator: Whitney Jones, MD, Clinical Professor of Medicine, University of Louisville

12:15 PM – 12:25 PM

• A review of the published data documenting delays in diagnosis and the consequences in terms of later stage diagnosis and poorer outcomes
  • Whitney F. Jones, MD, Gastro & Endo Associate

12:25 PM – 12:35 PM

• Overview of the continuum of providers who interact with patients prior to and up to a diagnosis
  • Chelsea Boet, MD, Spectrum Health Medical Group

12:35 PM – 12:45 PM

• Lessons Learned: What have we learned from past public health success stories?  
  • Jennifer Brown, PhD, NYC Department of Health & Mental Hygiene

12:45 PM – 12:55 PM

• Lessons Learned: What have we learned from past public health success stories?  
  • Tony Foleno, Senior Vice President, Strategy & Evaluation, Ad Council; President, Society for Health Communication

12:55 PM – 1:05 PM

• Introduction of the EAO-CRC National Clinical Alert and Symptoms and Signs Index
  • Andrew Albert, MD, MPH, Chicago Gastro LLC.
  • Erin Peterson, Colon Cancer Coalition
    • Provider Education Outreach Initiatives
    • Patient Awareness and Advocacy Initiatives

1:05 PM – 1:20 PM

• Q&A Panel Discussion – Strategic Plan Development

1:20 PM – 2:45 PM SESSION IV: TIMELY, EFFECTIVE, QUALITY OF LIFE & FERTILITY PRESERVING STATE OF THE ART TREATMENT (ADDRESSING GAP 3)  

1:20 PM – 1:30 PM

• Updates on Current Medical Oncology Approaches to Young-Onset CRC
  • Andrea Cercek, MD, Memorial Sloan Kettering Cancer Center

1:30 PM – 1:40 PM

• Optimal Preservation of Fertility  
  • Nicole Noyes MD, Reproductive Endocrinologist, Northwell Health

1:40 PM – 1:50 PM

• Novel Approaches to Metastatic Mismatch Repair (MMR) deficient and Microsatellite Stable (MSS) metastatic Colorectal Cancer
  • Cathy Eng, MD, FACP, FASCO, The University of Texas MD Anderson Cancer Center

1:50 PM – 2:00 PM

• From “Bench to Bedside” CRC Experimental Therapeutics and Phase I & II Trials. What’s New & What’s Next?
  • Wasif M. Saif, MD, MBBS Northwell Health Cancer Institute

2:00 PM – 2:10 PM

• GAPS in providing Palliative Care and the cost benefit ratio for hospital systems
  • James T. D’Olimpio, MD, FACP, FAAHPM North Shore University Hospital

2:10 PM -2:20 PM

• Q&A Panel Discussion

2:20 PM – 2:35 PM

• Identifying the Key Elements of a Center for Early Age Onset Colorectal Cancer – Panel Discussion
  • Eric Reddy, Stage IV Colorectal Cancer Survivor
  • Andrea Cercek, MD, Memorial Sloan Kettering Cancer Center
  • Zana Correa, NP, Memorial Sloan Kettering Cancer Center
  • Kimmie NG, MD, MPH, Dana-Farber Cancer Institute
  • Karen Fasciano, PsyD, Dana-Farber Cancer Institute
  • Christine Louise S. Molmenti, MPH, PhD Feinstein Institute for Medical Research/ Northwell Health
  • Thomas K. Weber, MD, FACS, Northwell Health, Colon Cancer Foundation
  • Krista Nelson, LCSW OSW-C BCD FAOSW, Providence Cancer Institute, Providence St Joseph Health

2:35 PM – 2:45 PM

• Q&A Panel Discussion – Strategic Plan Development

2:45 PM – 3:00 PM

• Networking, Coffee, Poster Viewing Break

3:00 PM – 5:35 PM SESSION V: HOW DID THIS HAPPEN? INVESTIGATING THE CAUSES OF EARLY ONSET COLORECTAL CANCERS (EAO-CRC) (ADDRESSING GAP 4)

The Genetics of Heritable CRC: What’s New and Important to Know Regarding the Genetics of EAO-CRC? Moderators: Professors Kauff & Weber

Moderator(s): Noah D. Kauff, MD, Duke Cancer Institute, Duke University Health System and Thomas K. Weber, MD, FACS, Northwell Health, Colon Cancer Foundation

3:00 PM – 3:10 PM

• Prevalence and Spectrum of Germline Cancer Susceptibility Gene Mutations Among Patients with Early-Onset Colorectal Cancer.
  • Heather Hampel, MS, LGC, The Ohio State University Comprehensive Cancer Center

3:10 PM – 3:20 PM

• Molecular subtype of colorectal cancer associated with early age of onset
  • Xavier Llor, MD, PhD, Yale University School of Medicine Smilow Cancer Center

3:20 PM – 3:30 PM

• Germline Genetic Variants Associated with Young-Onset Colorectal Cancer: The MSKCC Experience   
  • Zsofia K. Stadler, MD Clinical Director, Clinical Genetics Service, Memorial Sloan Kettering Cancer Center

3:30 PM – 3:40 PM

• Germline Genetic Features of Young Individuals with Colorectal Cancer
  • Elena M. Stoffel MD MPH, Director Cancer Genetics Clinic, University of Michigan

3:40 PM – 3:50 PM

• Cancer Susceptibility Gene Mutations in Individuals With Colorectal Cancer
  • Matthew B. Yurgelun MD, Dana-Farber Cancer Institute, Harvard Medical School

What is driving the increases in EAO-CRC,  80 + % of which is NOT related to the Named Hereditary CRC Syndromes ?   

3:50 PM – 4:00 PM

• Obesity, Sedentary Behaviors, and Early-Onset CRC,  Yin Cao, MPH, ScD, MPH, Washington University School of Medicine

4:00 PM – 4:10 PM

• New Suspects: Diet, Microbiome, Immunology and Cancer Risk, Semir Beyaz, PhD, Cold Spring Harbor Laboratories

4:10 PM – 4:20 PM

• New Research Information: Current Efforts to investigate the causes of increases in MSS CRC among young adults.
  • The United States:
    • Current NCI Funded Investigations into the Causes of Early Age Onset Colorectal Cancer:

• • • • • Colorectal Cancer Risks in People < 50 Years of Age  NIH (RO3): Epidemiology, Richard Hayes, DDS, PhD, MPH, The Cancer Institute at NYU Langone

4:20 PM – 4:30 PM

• Presentation Early Life Risk Factors and Risk of Colorectal Neoplasia, Kana Wu, MD, PhD, Harvard T.H. Chan School of Public Health, Dana-Farber, Harvard Cancer Center

4:30 PM – 4:40 PM

• The European Union: Funded Investigations 
  • European Organization for Research and Treatment of Cancer (EORTC): Young Onset CRC: Causation, Treatment and Outcomes, Irit Ben-Aharon, MD, PhD, Rambam Health Care Campus, Haifa, Israel European Organisation for Research and Treatment of Cancer

4:40 PM – 4:50 PM

• European study of Early-onset Colorectal Cancer (EUREOC): A Collaborative Study of the Biology of Young Onset CRC, Jose Perea, MD, PhD, Fundacion Jimenez Diaz University Hospital, Madrid, Spain

4:50 PM – 5:00 PM

• In Development: CRAYON: ColoRectal Cancer in Adults at Young ONset: New York City Based Prospective Accrual Study of Young Onset Colorectal Cancer
  • Steven H. Itzkowitz MD, Icahn School of Medicine at Mount Sinai

5:00 PM – 5:10 PM

• The Beyond CRC Project  
  • Kimmie Ng, MD, MPH, Dana-Farber Cancer Institute

5:10 PM – 5:20 PM

• The Search for Novel Drivers of Young Onset MSS CRC: An overview of current NIH, CDC and ACS efforts, Thomas K. Weber, MD, FACS, Northwell Health

5:20 PM – 5:30 PM

• Report back from Denver EAO CRC Research Meeting, Heather Hampel, The Ohio State University Comprehensive Cancer Center

5:30 PM – 5:45 PM

• Discussion and “Next Steps”

5:45 PM – 6:45 PM

• Poster Session and Reception

FRIDAY, MAY 3, 2019

8:00 AM – 9:00 AM REGISTRATION AND BREAKFAST WITH THE DOCTORS (Krista Nelson and Karen Fasciano)

9:00 AM – 9:05 AM WELCOME BACK!

Course Co-Director Wasif M. Saif, MD, MBBS, Northwell Health Cancer Institute

9:00 AM – 9:05 AM HOUSEKEEPING

Course Co-Director Susan Peterson, PhD, MPH, The University of Texas MD Anderson Cancer Center

9:05 AM – 10:05 AM

SESSION VI: PALLIATIVE CARE: WHY EARLY IS BEST. (INCLUDING GUIDANCE, SUPPORT AND RESOURCES TO PATIENTS AND CAREGIVERS DURING THEIR TREATMENT JOURNEY/CONTINUUM OF CARE.  (ADDRESSING GAP 5)

James T. D’Olimpio, MD, FACP, FAAHPM North Shore University Hospital

Sarah Debord, Colon Cancer Coalition

Andy Esch, MD, MBA, Palliative Care and Survivorship of Western New York

Karen Fasciano, PsyD, Dana-Farber Cancer Institute

Susan Pfau,

Krista Nelson, LCSW OSW-C BCD FAOSW,

10:05 AM – 10:25 AM

SESSION VI EPIGENETICS AND ITS FUTURE ROLE IN THE DIAGNOSIS AND TREATMENT OF INDIVIDUALS MORE SPECIFICALLY AND ACCURATELY

1. Richard Boland, MD, AGAF, UC San Diego

10:25 AM – 10:45 AM

• Networking, Coffee, Poster Viewing Break

10:45 AM – 11:20 PM

STRATEGIC PLANNING SESSION (BREAKOUT GROUPS ACCORDING TO GAP)

1. Data, accurate, regular to measurement of key metrics
2. Family History Ascertainment
3. Earliest Possible Stage Diagnosis
4. Development of centers of excellence dedicated to the treatment of EAO CRC patients and caregivers
5. Research into the causes of early onset colorectal cancers

11:20 AM – 11:45 PM

REPORT BACK FROM STRATEGIC ACTION PLAN BREAKOUT GROUPS

THE EAOCRC PLEDGE

11:45 PM – 12:15 PM

ABSTRACT POSTER SESSION AWARDS

CLOSING REMARKS

Accreditation:  This live activity has been be planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education through the joint providership of Northwell Health and The Colon Cancer Foundation. Northwell Health is accredited by the Accreditation Council for Continuing Medical Education to provide Continuing Medical Education for physicians.

Credit Designation:  Northwell Health designates this live activity for a maximum of 11.25 AMA PRA Category 1 Credits ™. Physicians should only claim credit commensurate with the extent of their participation in the activity

Disclosure Policy:  Northwell Health adheres to the ACCME’s Standards for Commercial Support. Any individuals in a position to control the content of a CME activity, including faculty, planners, reviewers or others, are required to disclose all relevant financial relationships with commercial interests. All relevant conflicts of interest will be resolved prior to the commencement of the activity.

LINK TO ABSTRACTS HERE

Deadline for submission EXTENDED THROUGH SUNDAY MARCH 31, 2019. Accepted posters and authors will be notified by April 5th. 

The EAO-CRC Program Planning Committee invites attendees to submit abstracts for a poster presentation at the fifth annual meeting on May 2-3, 2019.  Abstracts may describe research or programs, and may have been presented elsewhere.

** Please remember to register for the 5th Annual Early Age Onset Colorectal Cancer Summit before March 30, 2019 to qualify for early bird pricing.

** Please remember to book your hotel.

ABSTRACT SUBMISSION GUIDELINES

Abstracts should be submitted as an MS Word document to the following email address:  abstracts@coloncancerfoundation.org. Abstracts should include a title, and name(s) of all author(s) and their institution or organization affiliation.  The name of the presenting author should be underlined.  The body of the abstract should not exceed 350 words.  See below for guidelines specific to the body of research and program abstracts.

Research abstracts.  Abstracts describing scientific research on early age onset colorectal cancer should organize the content using the following subheadings:  Background, Methods, Results, and Conclusions. One data table is permitted per abstract. Illustrations and figures are not permitted. Define all abbreviations. Include the abstract title, full names and institutional affiliations of all authors, and email address of the corresponding author at the top of the abstract. Underline the name of the presenting author. Abstracts must not contain copyrighted material unless permission has been obtained by the author. Indicate at the bottom of the page if the abstract has been presented elsewhere and at what meeting. Submitted abstracts not meeting the above specifications will be returned. Any and all relevant conflicts of interest need to be noted at the bottom of the abstract.

Any questions regarding abstract submission should be directed to abstracts@coloncancerfoundation.org

Program abstracts. Abstracts describing programs focused on any aspect of early age onset colorectal cancer should organize the content using the following subheadings:  Program Objectives, Audience, Program Description, Future Directions.  One table is permitted per abstract.  Illustrations and figures are not permitted. Define all abbreviations. Include the abstract title, full names and institutional affiliations of all authors, and email address of the corresponding author at the top of the abstract. Underline the name of the presenting author. Abstracts must not contain copyrighted material unless permission has been obtained by the author. Indicate at the bottom of the page if the abstract has been presented elsewhere and at what meeting. Submitted abstracts not meeting the above specifications will be returned. Any and all relevant conflicts of interest need to be noted at the bottom of the abstract.

Any questions regarding abstract submission should be directed to abstracts@coloncancerfoundation.org

POSTER PRESENTATION SESSIONS

Poster presentations will provide an opportunity for interchange of ideas between the presenter and EAO CRC Summit attendees in his/her study. The poster should be outlined so the research can be understood without an oral explanation as a poster may also be viewed when the author is not present.

Poster location to be determined. Posters will be easily accessible and available for viewing for the duration of the EAO CRC Summit including a reception to be held on the evening of May 2.

Set-Up: Will take place on Thursday, May 2 at 7:00 AM. Each poster will be assigned a sequential number. Locate your assigned poster board and mount your poster within the time noted on the instructions received once accepted. Pushpins will be provided in the area by the Moderators.

Format of poster is LANDSCAPE (horizontal).

Regular Poster Size Limitations: No larger than 47 inches high and 95 inches wide (120 cm high by 240 cm wide). This is the size of the poster board. Do NOT exceed the size of the poster board.

Photos, Charts, and Graphs: Charts, drawings, and illustrations should be similar to those you would use in making PowerPoint slides. If photographs are used, please have them processed with a matte or dull finish.

Contact Information: Please clearly print 1 email address on your poster for attendees to refer to should they have any questions or comments at a time when you are not standing with your poster. If you do not wish to print your own email address, please list another email address for an appropriate contact person for your abstract.

Poster Material: The poster can either be made on 1 sheet (rollup) or in several small sections. Do NOT mount illustrations on heavy cardboard because they may be difficult to keep in position on the poster board.

Take-Down: Will take place on Friday, May 3 by 12:30 PM. Please disassemble your posted materials at the end of the EAO CRC Summit. Any materials left on the poster board at the end of the session will be removed and disposed of.

AWARDS AND JUDGING

As part of the abstract review process the poster review committee will identify the top ranking abstracts. The top three abstracts will recognized during the EAO CRC Summit poster session. Awardees will also be recognized during the closing remarks and award ceremony. EAO CRC Summit attendees will also have the opportunity to review posters and vote for the People’s Choice Award.